Paget’s Disease of Bone
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Paget’s disease of bone is a chronic condition that slowly worsens over time. It is characterized by abnormally rapid bone reformation and abnormally rapid bone destruction (osteolytic) (osteoblastic). A structurally abnormal, dense, and brittle new bone may develop in one or more areas of the body. It is possible that the new bone will be dense. This abnormal development has the potential to cause pain in the bones, arthritis, deformities, and fractures. The vertebrae in the spine, skull, pelvis, and lower legs are the ones that are most frequently affected. There is a lack of consensus regarding what triggers Paget’s disease..